Treatment outcomes, case reports. Introduction to types of cancer and number of cases treated at the New City Osaki Clinic

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“Osaki method” of test of immunological capacity

Reason for testing immunological capacity regularly

How can we determine whether or not immune cell therapy including NK cell therapy is effective for cancer?
The efficacy of a certain therapy is often evaluated based on reduction of the size of cancer on the CT image. However, immunotherapy is frequently used with anticancer agents and it is difficult to tell whether the observed effect comes from immunotherapy. Originally, efficacy evaluation based on the reduction of the size of cancer is suitable for anticancer agents, but not appropriate for immunotherapy. Therefore, it is generally considered that the efficacy of immunotherapy should be evaluated based on the prolonging of survival, which is the most reliable criterion for anticancer effect.

Nevertheless, survival benefit cannot be assessed in the first month of immunotherapy. How, then, should we evaluate the efficacy of immunotherapy?

We are certain that immunotherapy causes some changes in the immune cells in blood circulating in the body. If immunotherapy does not lead to any immunological change in the body, we cannot call it immunotherapy. We are sure about such mechanisms of immunotherapy because, when we examine the changes in the immune state of the entire body by regularly collecting blood during the treatment using the “Osaki method” of highly active NK cell therapy, we observed clear survival benefit in patients whose immune state represented by NK cell count or NK activity of blood was greatly improved.

At the New City Osaki Clinic, we comprehensively evaluate the six major indices of immunity for all the patients who receive our treatment and explain the results to these patients as their overall immunological capacity.


Cancer immunotherapy

Immune system | Cancer immunotherapy | Highly active NK cell therapy | Problems of highly active NK cells | Characteristics of highly active NK cells | “immunity-enhancing effect” of highly active NK cells | Recommendation of highly active NK cell therapy