Answers to questions to the New City Osaki Clinic

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Frequently asked questions

Q11 There are various other NK cell therapies. How is highly active NK cell therapy different from these other therapies?

The NK (natural killer) cell is one of the lymphocytes that are very difficult to proliferate, but many methods to increase NK cells have been reported. In these methods, collected lymphocytes are stimulated by mixing them with the Interleukin 2 or tumor cells. However, stimulation by highly concentrated Interleukin 2 actually increases the NK cells only by up to 10 times. In addition, activation usually reaches a peak from the fifth day to the seventh day of the culture and is lowered when culture is continued longer than that. When T cells are stimulated and activated by the culture, a molecule called “CD56” appears on the surface of a T cell. Because CD56 is a mark indicating NK cells, some people call the T cell presenting CD56 an NK cell. However, this is not a true NK cell.

The NK cells cultured at the New City Osaki Clinic are not activated T cells with CD56, but true NK cells. In order to prepare a large number of NK cells from 30 to 35 ml of blood, we use a newly developed unique method that allows for the growth of more than 10 billion NK cells.

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